Evidence supporting the use of: EGCG
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG), a major catechin found in green tea, has been studied for its potential anti-aging effects. Scientific interest in EGCG's role in aging stems primarily from its antioxidant, anti-inflammatory, and cellular protective properties. In laboratory and animal studies, EGCG has been shown to reduce oxidative stress, mitigate DNA damage, and activate cellular pathways associated with longevity, such as the SIRT1 pathway and AMPK signaling. These mechanisms are linked to healthier aging in model organisms. Additionally, EGCG may help protect against age-related diseases like cardiovascular disease and neurodegeneration, both of which are key contributors to the aging process.

However, while in vitro (cell culture) and in vivo (animal) studies are promising, robust clinical evidence in humans is limited. Most human studies have focused on markers of oxidative stress, metabolic health, and disease risk rather than direct measures of aging or lifespan. Clinical trials evaluating the impact of EGCG supplementation on actual aging parameters (e.g., lifespan, physical function, cognitive decline) are lacking. Thus, while there is a scientific rationale and some supporting evidence for EGCG’s role in aging prevention, high-quality clinical data are insufficient, resulting in a modest evidence rating.

In summary, EGCG is scientifically investigated for anti-aging, but current evidence in humans is preliminary and does not establish efficacy for the prevention or treatment of aging.

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Products containing EGCG

We currently have no products on Caring Sunshine that contain this ingredient.