Evidence supporting the use of: Dodder
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Dodder (Cuscuta spp.) has a long history of use in traditional Chinese medicine (TCM), particularly the seeds known as "Tu Si Zi". In TCM, dodder seeds are believed to tonify the kidneys and liver, nourish yin and yang, and support vitality, which are associated with longevity and resistance to aging. Historical texts often recommend dodder as a remedy for symptoms commonly related to aging, such as fatigue, weakened vision, and decreased reproductive function. The conceptual framework in TCM connects kidney health with aging processes, and thus herbs like dodder are included in formulas designed to "slow aging" or "invigorate life force".

From a scientific perspective, there is limited but emerging evidence suggesting that dodder seed extracts possess antioxidant properties and may modulate certain biological pathways implicated in aging, such as oxidative stress and immune function. Some in vitro and animal studies have reported anti-aging effects, including improved antioxidant enzyme activity and reduced markers of cellular senescence. However, these findings are preliminary, and robust clinical trials in humans are lacking. As a result, while traditional use is strong and some early laboratory research is promising, scientific validation remains insufficient to fully endorse dodder as an anti-aging intervention. Thus, the use of dodder for aging prevention is primarily justified by tradition, with the current evidence level rated at 2/5.

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