Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cycloastragenol is a molecule derived from Astragalus membranaceus, a traditional Chinese medicinal herb. Its use for aging prevention is primarily supported by recent scientific interest rather than long-standing traditional use. Cycloastragenol has been investigated for its potential to activate telomerase, the enzyme responsible for maintaining telomere length. Telomeres are protective DNA sequences at the ends of chromosomes that shorten with each cell division, and critically short telomeres are associated with cellular senescence and aging.

Preclinical studies, mainly in cell cultures and animal models, have shown that cycloastragenol can stimulate telomerase activity, leading to increased telomere length and potentially delayed senescence in some cell types. A few small human studies and pilot trials (often involving dietary supplements such as TA-65) have reported modest improvements in immune function and some biomarkers associated with aging, but these studies are generally limited by small sample sizes, lack of robust controls, and short durations.

There is currently no high-quality, long-term clinical evidence demonstrating that cycloastragenol supplementation leads to increased lifespan, prevention of age-related diseases, or substantial improvements in human healthspan. The available evidence justifies cautious optimism but does not yet support strong claims for its effectiveness in aging prevention. More rigorous and large-scale clinical trials are needed to establish its safety and efficacy in humans.

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