Evidence supporting the use of: Collagen
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Collagen supplementation has gained popularity as a means of supporting skin health and preventing visible signs of aging, such as wrinkles and decreased skin elasticity. Scientific evidence for the efficacy of oral collagen supplementation is steadily growing. Several randomized controlled trials have demonstrated that ingesting hydrolyzed collagen peptides can improve skin elasticity, hydration, and dermal collagen density in healthy adults, particularly women aged 35 and over. For example, a 2019 systematic review published in the Journal of Drugs in Dermatology found that daily oral collagen supplements for 8–12 weeks led to statistically significant improvements in skin elasticity and moisture compared to placebo. The proposed mechanism involves the absorption of collagen peptides, which may stimulate the body's own collagen production by activating fibroblasts in the dermis.

However, it should be noted that not all studies have found dramatic benefits, and most research so far is industry-sponsored with relatively small sample sizes. There is also debate about how much of the ingested collagen is absorbed intact and incorporated into skin tissue. While topical collagen is less well supported due to poor penetration, oral supplementation does have a plausible biological basis and a growing number of supportive clinical studies. Overall, while more independent, large-scale research is needed, current evidence moderately supports the use of collagen for aging prevention, particularly for improving skin appearance and hydration.

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Other ingredients used for Aging (prevention)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
7-hydroxymatairesinol (HMR)
7-Keto-DHEA
8-Prenylnaringenin
Abalone
Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
Algae
algal oil
Algal protein
Allantoin
Almond fruit
Alpha hydroxy acids
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anemarrhena asphodeloides
anserine
anthocyanidins
anthocyanins
anthocyanosides
antler
Antrodia camphorata
apigenin
apple
apricot
argan nut oil
Aronia melanocarpa
ascorbyl palmitate
ashitaba
ashwagandha
astaxanthin
astragaloside
astragalus
avocado
beta-carotene
bioflavonoids
bird\'s nest
Brassica
Brussel sprouts
Carnosine
carotene (unspecified)
carrot
catalase
cauliflower
Chinese Ligustrum berry
cistanche
coenzyme Q10 (CoQ10)
collagen
cruciferous
cryptoxanthin
curcumin
Curcuminoid
cycloastragenol
DHEA
DHEA (dehydroepiandrosterone)
dismutase
dodder
Dunaliella
Dunaliella salina
ellagic acid
epicatechin
Epidermal Growth Factor
epigallocatechin gallate (EGCG)
ergothioneine
fibroblast growth factor
fisetin
flavonoids
flaxseed
fo-ti
fucoxanthin
Gac
Gerovital H3
ginkgo biloba
Ginsenosides
Glabridin
goji berry
green tea
greens blend (proprietary)
Haematococcus pluvialis
hazelnut
HMB hydroxymethylbutyrate
hydroxymethylbutyrate
icariin
L-carnosine
lutein
Lycium
magnesium
Matcha
Melatonin
mixed carotenoids
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oolong tea
Peptides
Phytoene
Phytofluene
polypeptide complex (proprietary)
polyphenols
protein
pyrroloquinoline quinone
quercetin
resveratrol
Rhodiola
royal jelly
Salidroside
selenium
Shilajit
silicon
soy isoflavones
soybean
Squalene
Trans-pterostilbene
Tremella
Triterpenes
turmeric
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
Watermelon
Xanthophyll
Yerba mate
Zinc
β-nicotinamide mononucleotide (NMN)