Evidence supporting the use of: Coenzyme Q10 (CoQ10)
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant involved in the mitochondrial electron transport chain, essential for cellular energy production. Its levels tend to decrease with age, leading to speculation that supplementation might help counteract aging-related declines in cellular function. Several animal and in vitro studies have demonstrated that CoQ10 can reduce oxidative stress, a contributor to cellular aging. Small clinical trials in humans suggest possible benefits, such as improved skin elasticity and reduced wrinkle depth, attributed to its antioxidant activity. Additionally, some research indicates CoQ10 may support cardiovascular health and cognitive function in older adults, though these effects are modest and not universally observed. However, large, well-controlled clinical trials specifically examining CoQ10's effects on human aging are lacking. Most available evidence for anti-aging effects comes from surrogate endpoints (e.g., oxidative stress markers, mitochondrial function) rather than direct measures of aging or longevity. Systematic reviews generally conclude that while CoQ10 is safe for most people, robust evidence supporting its efficacy for aging prevention is insufficient at this time. Thus, while its use is grounded in mechanistic plausibility and supported by preliminary studies, the overall strength of evidence is low.

More about coenzyme Q10 (CoQ10)
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Other ingredients used for Aging (prevention)

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
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Dismutase
DHEA
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Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
Fo-Ti
Fucoxanthin
fibroblast growth factor
Ginsenosides
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Gerovital H3
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