Evidence supporting the use of: Coenzyme Q10 (CoQ10)
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant involved in the mitochondrial electron transport chain, essential for cellular energy production. Its levels tend to decrease with age, leading to speculation that supplementation might help counteract aging-related declines in cellular function. Several animal and in vitro studies have demonstrated that CoQ10 can reduce oxidative stress, a contributor to cellular aging. Small clinical trials in humans suggest possible benefits, such as improved skin elasticity and reduced wrinkle depth, attributed to its antioxidant activity. Additionally, some research indicates CoQ10 may support cardiovascular health and cognitive function in older adults, though these effects are modest and not universally observed. However, large, well-controlled clinical trials specifically examining CoQ10's effects on human aging are lacking. Most available evidence for anti-aging effects comes from surrogate endpoints (e.g., oxidative stress markers, mitochondrial function) rather than direct measures of aging or longevity. Systematic reviews generally conclude that while CoQ10 is safe for most people, robust evidence supporting its efficacy for aging prevention is insufficient at this time. Thus, while its use is grounded in mechanistic plausibility and supported by preliminary studies, the overall strength of evidence is low.

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