Evidence supporting the use of: Ceramide
For the health condition: Aging (prevention)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Ceramide is a lipid molecule naturally found in high concentrations within cell membranes in the upper layer of the skin (stratum corneum). Its primary role is to maintain the skin’s barrier function and retain moisture. As the skin ages, ceramide levels decrease, leading to dryness, increased sensitivity, and a compromised barrier, all of which contribute to visible signs of aging such as fine lines, wrinkles, and rough texture.
Scientific studies have demonstrated that topical application of ceramides (in creams, lotions, or serums) can help replenish the skin's natural lipid barrier, thereby improving hydration, reducing trans-epidermal water loss, and enhancing the skin's resilience. Some research indicates that ceramide-containing formulations can improve the appearance of aging skin, especially when combined with other skin-identical lipids (like cholesterol and free fatty acids). For example, a 2018 review in the Journal of Dermatological Science discusses the role of barrier lipids in skin aging and supports the use of topical ceramides for barrier repair and maintenance.
However, while the evidence for barrier improvement and hydration is strong, direct evidence for ceramides’ ability to prevent or reverse deeper signs of intrinsic aging (such as collagen loss or deep wrinkles) is more limited. Most of the benefits relate to improved skin texture and moisture, which can indirectly reduce the appearance of fine lines. Overall, ceramides are a scientifically validated ingredient for supporting the skin’s barrier and mitigating some visible signs of aging, though they are best used as part of a broader anti-aging regimen.
Other ingredients used for Aging (prevention)
7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Ellagic Acid
Other health conditions supported by Ceramide
Aging (prevention)Cancer (natural therapy for)
Eczema
Inflammation
Psoriasis
Skin (dry and/or flaky)
Skin Care (general)
Wrinkles