Evidence supporting the use of: Ampelopsin
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ampelopsin (also known as dihydromyricetin, DHM) is a flavonoid compound primarily found in the Japanese raisin tree (Hovenia dulcis) and certain species of Ampelopsis. There is emerging, but still limited, scientific evidence supporting its potential role in aging prevention. Preclinical studies, mostly in vitro and in animal models, suggest that ampelopsin possesses antioxidant, anti-inflammatory, and senolytic properties. For example, research has shown that ampelopsin can reduce oxidative stress and modulate pathways associated with cellular aging, such as the SIRT1 and AMPK pathways. Some studies report that it may delay cellular senescence and protect against age-related decline in organ function in rodents.

However, there are currently no robust clinical trials in humans directly demonstrating that ampelopsin slows aging or prevents age-related diseases. Its use in traditional medicine has been more focused on liver health and intoxication relief rather than aging per se. While the molecular mechanisms observed in laboratory settings are promising, the translation to human aging prevention remains unproven. Thus, the evidence base is preliminary, and more rigorous human studies are needed before ampelopsin can be recommended for aging prevention with confidence.

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Products containing Ampelopsin

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