Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) is a naturally occurring compound that functions as a cofactor for mitochondrial enzymes and is recognized for its potent antioxidant properties. Its proposed role in aging prevention is primarily based on its ability to combat oxidative stress, a key contributor to the aging process and age-related diseases. Preclinical studies in animal models have shown that ALA supplementation can improve mitochondrial function, reduce oxidative damage, and, in some cases, extend lifespan. Additionally, ALA has been studied for its potential to improve insulin sensitivity and reduce inflammation—both factors implicated in the aging process. In humans, the evidence supporting ALA for aging prevention is limited and less robust. Some small clinical trials have demonstrated improvements in markers of oxidative stress and inflammation, particularly in populations with metabolic disorders. However, there is a lack of large, well-controlled studies directly linking ALA supplementation to slowed aging or reduced incidence of age-related diseases in healthy adults. As such, while the mechanistic rationale and animal data are promising, clinical evidence remains preliminary. Overall, the use of alpha lipoic acid to support aging prevention is scientifically motivated but currently supported by low to moderate quality evidence. More rigorous human studies are needed to clarify its efficacy for this indication.

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Products containing alpha lipoic acid

Nature's Sunshine Alpha Lipoic Acid
Nature's Sunshine Brain Protex (With Huperzine A)
Nature's Sunshine Cellular Energy
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Nature's Sunshine Super Antioxidant
Nature's Sunshine VitaWave