Synopsis

Source of validity: Scientific
Rating (out of 5): 2

7-keto (7-oxo-dehydroepiandrosterone-acetate) is a metabolite of dehydroepiandrosterone (DHEA), a hormone naturally produced by the adrenal glands. Its use for aging prevention is grounded more in emerging scientific exploration than in traditional medicine. Some small clinical studies and preclinical research have investigated 7-keto’s potential for improving metabolism and immune function, both of which tend to decline with age. Animal studies suggest that 7-keto may enhance thermogenesis (the process of heat production in organisms) and support energy expenditure, which could indirectly counteract age-related weight gain. Limited human trials have shown modest effects on metabolic rate in overweight adults, but there is no clear evidence that this translates to broader anti-aging effects or increased lifespan.

Unlike DHEA, 7-keto does not convert to sex hormones such as estrogen or testosterone, which may reduce the risk of hormone-related side effects. However, robust human clinical trials specifically examining anti-aging outcomes (such as improved vitality, cognitive function, or delayed onset of age-related diseases) are lacking. As a result, while 7-keto is often marketed as an “anti-aging” supplement, scientific support for this claim is weak and largely extrapolated from indirect or mechanistic studies. The evidence rating is 2 out of 5, reflecting limited and preliminary human data with a need for more rigorous research.

More about 7-Keto-DHEA
More about Aging (prevention)

Other ingredients used for Aging (prevention)

Other health conditions supported by 7-Keto-DHEA

Products containing 7-Keto-DHEA

Nature's Sunshine 7-Keto