Synopsis

Source of validity: Scientific
Rating (out of 5): 2

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid is better known as ferulic acid, a compound found in the cell walls of plants such as rice, oats, and wheat. Its use in aging prevention is primarily based on its antioxidant properties. A number of in vitro and animal studies have demonstrated that ferulic acid can neutralize free radicals and reduce oxidative stress, which is considered a significant factor in the aging process and age-related diseases. For example, studies published in peer-reviewed journals indicate that ferulic acid helps protect skin cells from UV-induced damage and reduces markers of inflammation and oxidative damage in animal models. Additionally, topical application of ferulic acid has been reported to stabilize vitamins C and E, enhancing their photoprotective effects in human skin.

However, despite this scientific plausibility and preliminary evidence, there is a lack of large-scale human clinical trials explicitly demonstrating anti-aging effects in vivo, either for skin aging or general aging prevention. Most evidence is preclinical or based on laboratory studies; thus, the clinical significance for humans remains to be conclusively established. In summary, ferulic acid’s use in aging prevention is supported by a moderate scientific rationale and laboratory evidence, but direct clinical evidence in humans is limited, justifying a rating of 2 out of 5.

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