Evidence supporting the use of: Polypeptide complex (proprietary)
For the health condition: Age Spots
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Polypeptide complexes, often termed "proprietary" in cosmetic formulations, are blends of short chains of amino acids designed to mimic naturally occurring peptides in the skin. These peptides are involved in cellular signaling and can influence processes such as collagen production, skin barrier repair, and pigmentation. While there is some laboratory and clinical evidence suggesting that certain peptides (such as oligopeptides, hexapeptides, and copper peptides) can modulate melanin synthesis and support skin repair, the evidence specifically supporting polypeptide complexes for treating or reducing age spots (also known as solar lentigines or hyperpigmentation) is limited and varies based on the specific peptide blend. A few studies have shown that peptides may decrease melanin production by interfering with melanogenesis pathways, potentially lightening hyperpigmented areas. However, most available clinical data involve either small peptides or single molecules, not complex proprietary blends. Additionally, results from in vitro (cell culture) studies and animal models do not always translate directly to clear benefits in human skin. Overall, while the inclusion of polypeptide complexes in age spot treatments is based on a scientific rationale—given their potential to influence skin repair and pigmentation—the direct clinical evidence for efficacy in fading age spots is modest. Most claims are extrapolated from broader anti-aging or skin-brightening effects rather than robust, targeted clinical trials. Thus, the scientific evidence supporting their specific use for age spots currently rates as low to moderate.
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