Phytofluene is a colorless carotenoid found in certain fruits and vegetables, most notably tomatoes. It is known for its antioxidant properties and its ability to absorb ultraviolet (UV) light. The interest in phytofluene for age spots (also known as solar lentigines or liver spots) arises from its potential to counteract oxidative stress and protect skin from UV-induced damage, both of which are major contributors to the formation of age spots.

Several in vitro and animal studies have demonstrated that phytofluene can mitigate oxidative damage and modulate inflammatory responses in the skin. Furthermore, a handful of small human studies and clinical trials evaluating tomato extract supplementation (which includes phytofluene among other carotenoids) indicate that regular oral or topical use may improve skin photoprotection and reduce pigmentation irregularities caused by UV exposure. However, these studies often investigate carotenoid complexes rather than isolated phytofluene, making it difficult to attribute the effects specifically to phytofluene.

Overall, while there is some preliminary scientific evidence suggesting that phytofluene may help prevent or reduce age spots through its antioxidant and photoprotective actions, the direct evidence—especially from well-powered, peer-reviewed clinical trials focusing solely on phytofluene—is limited. Thus, the evidence supporting its use for treating or preventing age spots is modest but growing.