Evidence supporting the use of: Ganoderma
For the body system: Adrenal Glands

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ganoderma, commonly known as Reishi mushroom (Ganoderma lucidum), has a long history of use in traditional Chinese medicine (TCM) for supporting overall vitality, resilience, and stress adaptation. In TCM, Ganoderma is considered an "adaptogen," thought to help the body cope with various stressors, which indirectly relates to the function of the adrenal glands (organs responsible for stress hormone production, such as cortisol and adrenaline). Historical texts and herbal compendiums often cite Reishi for its role in balancing energy, enhancing longevity, and supporting the immune system, all of which are linked to the body's stress response. However, direct scientific evidence specifically linking Ganoderma to adrenal gland health or function is limited. Most modern research on Ganoderma focuses on its immunomodulatory, anti-inflammatory, and antioxidant effects, rather than its impact on adrenal hormones or the hypothalamic-pituitary-adrenal (HPA) axis. Some preclinical studies suggest adaptogenic effects, but these are not robustly demonstrated in human clinical trials addressing adrenal health specifically. In summary, while Ganoderma is traditionally used to support the body's stress response—implying a benefit for adrenal function—current scientific evidence supporting this specific use is limited. Its use for adrenal support is grounded primarily in traditional herbal practice rather than direct scientific validation.

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