Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Adrenal cortex extracts have been used in traditional and alternative medicine, particularly in the mid-20th century, to "support" adrenal gland function and address conditions like adrenal fatigue, Addison's disease, or stress-related fatigue. The rationale was that consuming adrenal tissue might help replenish or stimulate one's own adrenal hormones. Historically, these extracts were seen in early formulations before the development of synthetic corticosteroids. However, rigorous scientific validation is lacking—modern medicine now treats adrenal insufficiency with well-defined hormone replacement therapies, not glandular extracts. The use of adrenal cortex extracts persists mainly in naturopathic and some integrative circles, where anecdotal reports and tradition are cited, but few controlled studies exist. Concerns also exist regarding product standardization and safety, as hormone content can vary and may pose risks. Major regulatory agencies do not endorse their use. In summary, while adrenal cortex has a history of traditional use to "support" the adrenal glands, scientific evidence for its efficacy and safety is minimal, leading to a low evidence rating.

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