Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Licorice (Glycyrrhiza glabra) has a long history of traditional use in herbal medicine for supporting the adrenal glands and combating symptoms associated with what is now often called "adrenal fatigue." The concept of adrenal fatigue itself is not widely recognized in mainstream medicine, but in alternative and traditional health circles, licorice is commonly recommended. The rationale stems from licorice root’s ability to inhibit the enzyme 11β-hydroxysteroid dehydrogenase type 2, which results in prolonged activity of cortisol, a key hormone produced by the adrenal cortex. Historically, licorice was used in various systems of medicine (including Traditional Chinese Medicine and Ayurveda) for fatigue, weakness, and as a general adaptogen.

Scientific studies exist showing that licorice can affect cortisol metabolism and may be beneficial in cases of diagnosed adrenal insufficiency (such as Addison’s disease), but evidence for its efficacy in "adrenal fatigue"—a condition not officially recognized in evidence-based medicine—is lacking. Thus, the use is primarily justified by tradition and theoretical mechanisms rather than robust scientific validation. The evidence rating of 2 reflects that while there are plausible mechanisms and some support from traditional use, high-quality clinical trials for licorice's effectiveness in treating "adrenal fatigue" specifically are absent.

More about Licorice (unspecified)
More about Adrenal Fatigue

Other ingredients used for Adrenal Fatigue

Other health conditions supported by Licorice (unspecified)

Products containing Licorice (unspecified)