Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin C, including its fat-soluble form ascorbyl palmitate, is used to support the adrenal cortex primarily based on scientific understanding of vitamin C’s role in adrenal function. The adrenal glands contain high concentrations of vitamin C, and its levels are depleted during stress, which suggests a physiological demand. Vitamin C is involved in the biosynthesis of cortisol, a key hormone produced by the adrenal cortex, through its function as a cofactor for dopamine β-hydroxylase and other enzymes in steroidogenesis and catecholamine synthesis. Several animal studies and a limited number of human studies show that vitamin C supplementation can help normalize adrenal hormone secretion under stress or after adrenal stimulation, although most clinical research has focused on ascorbic acid rather than ascorbyl palmitate. Ascorbyl palmitate is used in supplements for its greater lipid solubility and stability, but direct clinical trials specifically evaluating ascorbyl palmitate and adrenal health are lacking. Overall, while there is a scientific rationale and some supporting evidence for vitamin C’s role in adrenal health and function, high-quality human trials specifically linking ascorbyl palmitate to adrenal cortex support are limited, justifying a moderate rating.

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