Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B complex, particularly B5 (pantothenic acid), B6 (pyridoxine), and B12 (cobalamin), is commonly used to support the adrenal cortex, which is responsible for producing stress-related hormones such as cortisol. The scientific rationale is based on the role of these vitamins as essential co-factors in the biosynthesis of adrenal hormones and in cellular energy metabolism. Research in animals and in vitro models shows that deficiency of B vitamins can impair adrenal function and hormone production. Some small human studies and clinical observations also suggest that B vitamins may help normalize adrenal function in cases of deficiency or chronic stress. However, high-quality, large-scale clinical trials directly demonstrating a benefit of B vitamin supplementation for adrenal support in healthy humans are lacking. Most evidence is indirect or comes from studies of people with deficiencies or high stress loads. Thus, while there is a plausible biochemical basis and some preliminary evidence, the strength of evidence for B vitamins as adrenal cortex supporters in the general population is moderate at best, and supplementation is most clearly justified in cases of deficiency, poor diet, or increased physiological demand.

More about vitamin B
More about Adrenal Cortex

Other ingredients that support Adrenal Cortex

Other body systems supported by vitamin B

Products containing vitamin B