Evidence supporting the use of: Rhodiola
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rhodiola rosea is an adaptogenic herb traditionally used in Russia, Scandinavia, and other parts of Europe and Asia to enhance resilience to physical and mental stress. Its use to "support the adrenal cortex" is rooted in its adaptogenic properties, as the adrenal cortex is primarily responsible for producing stress hormones, such as cortisol. Several scientific studies have investigated rhodiola's effects on stress responses, fatigue, and mental performance. Clinical trials have shown that standardized extracts of rhodiola may reduce fatigue and improve symptoms of stress, likely by modulating the hypothalamic-pituitary-adrenal (HPA) axis, of which the adrenal cortex is a key component. For example, a systematic review published in 2011 (Ishaque et al., BMC Complement Altern Med) concluded that rhodiola extracts "may have beneficial effects on physical performance and mental fatigue" under stress. Animal studies suggest rhodiola can reduce stress-induced elevations in corticosterone (the rodent equivalent of cortisol), indicating a possible regulatory effect on adrenal cortex hormone output. However, while evidence supports rhodiola’s adaptogenic and anti-fatigue effects, direct effects specifically on the adrenal cortex in humans are less well-established, and most studies focus on subjective stress reduction or fatigue. Overall, there is moderate scientific support for rhodiola's role in supporting stress response systems involving the adrenal cortex, justifying a mid-level evidence rating.

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