Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylserine is a phospholipid that plays a crucial role in cell membrane structure and function, particularly in the brain. Its use as a supplement has been studied primarily for cognitive support and stress-related responses. Regarding the adrenal cortex and the broader "adrenal support," the scientific evidence is limited but not entirely absent. Some research indicates that phosphatidylserine may help modulate the body’s stress response by influencing cortisol levels, a hormone produced by the adrenal cortex. For example, small clinical studies have shown that phosphatidylserine supplementation can blunt the rise in cortisol following acute physical or mental stress. This effect is thought to occur via effects on the hypothalamic-pituitary-adrenal (HPA) axis, which governs stress hormone production.

However, direct evidence supporting phosphatidylserine for "adrenal cortex support" or as a treatment for adrenal fatigue or dysfunction is lacking. Most studies focus on healthy adults experiencing stress, not on those with diagnosed adrenal disorders. There is no substantial traditional use of phosphatidylserine for adrenal health, as its supplementation is a relatively recent development. In summary, while there is some scientific rationale for its use in managing stress-related cortisol elevations, the evidence is modest, and its role in directly supporting adrenal cortex function remains unproven.

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