Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Licorice (Glycyrrhiza glabra) has a long history of traditional use in herbal medicine, particularly in Asia and Europe, for supporting various body systems, including the adrenal cortex. Scientifically, licorice contains glycyrrhizin, a compound shown to inhibit the enzyme 11β-hydroxysteroid dehydrogenase type 2, which results in increased levels of cortisol by reducing its inactivation. This action can mimic the effects of corticosteroids, theoretically supporting adrenal function, particularly in cases of adrenal insufficiency or Addison’s disease. Some small clinical studies and case reports have indicated that licorice can prolong the half-life of endogenous cortisol, offering symptomatic relief in certain adrenal-related conditions. However, the evidence is moderate; most research is preclinical or based on small-scale human trials, and the clinical relevance for generalized adrenal "support" remains limited. Additionally, chronic or high-dose licorice use can pose health risks, including hypertension, hypokalemia, and fluid retention due to its mineralocorticoid effects. Thus, while there is a biochemical basis and some clinical justification for licorice’s effect on cortisol metabolism and the adrenal cortex, more robust, large-scale human studies are needed to fully validate its use for adrenal support.

More about Licorice (various)
More about Adrenal Cortex

Other ingredients that support Adrenal Cortex

Other body systems supported by Licorice (various)

Products containing Licorice (various)