Evidence supporting the use of: Ketosterones (unspecified)
For the body system: Adrenal Cortex

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ketosterones, particularly those derived from the plant Eurycoma longifolia (commonly known as Tongkat Ali), have a history of traditional use in Southeast Asian medicine. They are often employed as tonics or adaptogens, purported to support vitality, energy, and resilience to stress—functions linked to adrenal health. In traditional practices, these effects are interpreted as support for the adrenal cortex, which is involved in the body's stress response via corticosteroid hormone production.

However, scientific validation for the use of ketosterones specifically to support the adrenal cortex is limited. While some studies have explored the adaptogenic and anti-stress effects of extracts containing ketosterones (such as Tongkat Ali root), the research is generally preliminary and does not isolate ketosterones as the active component. Most clinical data focus on broader outcomes like mood, fatigue, or testosterone levels, rather than direct measures of adrenal cortex function. There are no well-controlled human trials directly linking ketosterones to improved adrenal cortex health or function.

In summary, the primary justification for using ketosterones to support the adrenal cortex comes from traditional medicine, rather than robust scientific evidence. The evidence rating reflects the presence of traditional use with some weak or indirect supportive research, but not direct scientific validation.

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