Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Guayusa (Ilex guayusa) is a caffeinated Amazonian holly traditionally consumed by indigenous peoples in Ecuador and Peru. Its primary historical use has been as a stimulant beverage, consumed for increased alertness, stamina, and ritual purposes. There is no robust tradition specifically linking guayusa to support of the adrenal cortex or adrenal function. However, because the adrenal cortex is involved in the body’s response to stress and the production of certain hormones (including cortisol and adrenaline), some modern herbalists and supplement manufacturers loosely associate stimulating plants like guayusa with "adrenal support." This association is not rooted in ethnobotanical tradition, nor is it strongly supported by scientific research.

Scientific studies on guayusa mainly focus on its caffeine, antioxidant, and polyphenol content, as well as its potential cardiovascular and metabolic effects. There is no direct evidence from clinical or preclinical studies that guayusa specifically benefits the adrenal cortex or supports adrenal health. Therefore, its use for this purpose is primarily based on its general stimulating properties and not on direct effects on the adrenal cortex. The evidence for guayusa supporting adrenal cortex function remains weak, and its traditional use does not specifically target this body system.

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