Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sophora flavescens, commonly known as Ku Shen, has a long-standing history of use in traditional Chinese medicine (TCM) for the treatment of various inflammatory and infectious conditions, including those that involve swollen lymph nodes (adenitis). In TCM, its bitter and cold properties are believed to clear heat, dry dampness, and reduce toxic swellings, which aligns with traditional approaches to managing adenitis.

Historically, Sophora flavescens is included in herbal formulas aimed at “detoxifying” and “reducing abscesses or swellings,” which may include cases of lymphadenitis caused by bacterial or viral infections. The main active constituents, such as matrine and oxymatrine, have demonstrated anti-inflammatory and antimicrobial effects in laboratory studies, but these studies are generally not specific to lymphadenitis or adenitis in clinical settings.

While these traditional uses are well-documented in herbal compendia and TCM literature, modern clinical trials specifically evaluating the efficacy of Sophora flavescens for adenitis are lacking. Most available scientific evidence pertains to its general anti-inflammatory and antimicrobial potential, not direct clinical outcomes for adenitis. Therefore, the justification for its use in adenitis is primarily traditional, with limited supportive evidence from modern scientific studies.

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