Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Glandular tissues, specifically extracts from animal adrenal glands, have a long history of use in the treatment of Addison’s disease, but this use is primarily based on traditional medical practice rather than modern scientific validation. Before the isolation and synthesis of corticosteroid hormones in the 20th century, physicians sometimes prescribed desiccated (dried) adrenal gland extracts to patients with Addison’s disease, as the disease results from adrenal insufficiency. These extracts were thought to replace the missing hormones, and some patients reportedly experienced symptomatic improvement. However, the actual hormone content in these extracts was highly variable and often insufficient to effectively manage the disease.

With the advent of purified and standardized corticosteroid medications such as hydrocortisone and fludrocortisone, glandular extracts fell out of favor due to concerns about safety, efficacy, and consistency. Modern evidence-based medicine does not support the use of glandular tissues for Addison’s disease, as these extracts are unregulated, lack quality control, and may carry risks of contamination or immune reactions. Current medical guidelines recommend only pharmaceutical-grade steroid replacement therapy. Thus, while there is historical precedent for the use of glandular tissues in Addison’s disease, there is little scientific evidence to validate their efficacy or safety for this purpose.

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