Evidence supporting the use of: Cyanthillium cinereum
For the health condition: Addictions (tobacco smoking or chewing)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cyanthillium cinereum (also known as Little Ironweed) has been used traditionally in several Asian countries to help people quit tobacco smoking or chewing. However, beyond its traditional use, there is some scientific evidence suggesting it may be effective as a smoking cessation aid. Several small clinical studies conducted in Thailand and India have evaluated standardized extracts of C. cinereum for this purpose. A notable randomized controlled trial published in 2008 found that participants using the extract had higher 6-week abstinence rates compared to placebo, with statistically significant results. The proposed mechanisms include attenuation of withdrawal symptoms, reduction in nicotine craving, and possible mild monoamine oxidase inhibition. However, these studies tend to be limited by small sample sizes, short follow-up periods, and lack of replication in diverse populations. The World Health Organization’s South-East Asia Regional Office has cited C. cinereum as a potentially useful aid in tobacco cessation, primarily based on these studies. Nevertheless, large-scale, high-quality trials are lacking, and the evidence is not yet strong enough to support widespread recommendation in clinical practice outside of pilot programs or traditional settings. In summary, while there is some scientific evidence supporting its use, the overall quality and quantity of evidence is still limited, warranting a modest rating.

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Products containing Cyanthillium cinereum

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