Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutathione is a tripeptide involved in cellular antioxidant defense, detoxification, and immune function. Scientific interest in its use for Acquired Immune Deficiency Syndrome (AIDS) stems from the observation that people living with HIV/AIDS often exhibit low glutathione levels, particularly in T cells. Glutathione depletion has been implicated in impaired immune cell function and increased oxidative stress, both of which contribute to disease progression in HIV/AIDS. Some studies have explored whether oral or intravenous glutathione supplementation can improve immune parameters or clinical outcomes in this population.

Small clinical trials and in vitro studies have shown that glutathione supplementation may restore intracellular glutathione levels, enhance T-cell function, and reduce HIV replication in laboratory models. For example, research has demonstrated potential benefits in reversing oxidative stress and modulating immune response. However, the clinical significance of these findings remains limited, as large-scale, well-controlled human trials are lacking. The majority of existing evidence is preliminary, with mixed results regarding symptom improvement or slower HIV progression.

In summary, glutathione supplementation is not a standard or widely recommended treatment for AIDS, but there is a scientific rationale and some initial evidence for its use as a supportive therapy. The quality and quantity of evidence are insufficient to make strong clinical recommendations, placing the evidence rating at 2 out of 5.

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