Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coriolus mushroom, also known as Trametes versicolor or "turkey tail," has been investigated for its potential immunomodulatory effects, particularly in the context of Acquired Immune Deficiency Syndrome (AIDS). The primary bioactive components, polysaccharide-K (PSK) and polysaccharide-peptide (PSP), have demonstrated immune-stimulating properties in preclinical studies and have been used as adjuncts in cancer therapy, particularly in Japan and China. Limited scientific research has explored the direct effects of Coriolus mushroom in HIV/AIDS patients. Some in vitro and animal studies suggest that PSP and PSK may enhance immune function by increasing the activity of T-cells, natural killer cells, and cytokine production. Small early-phase clinical trials from China have reported immune-boosting effects in HIV-positive individuals, such as increased CD4+ T-cell counts and improved quality of life, but these studies often have methodological limitations, including small sample sizes and lack of rigorous controls. There is not yet robust clinical evidence from large, well-controlled trials to support the routine use of Coriolus mushroom as a treatment for AIDS. However, its use is supported by preliminary scientific findings indicating possible immune-supportive effects. Therefore, while there is a scientific basis for its investigation, the overall level of evidence remains low, and Coriolus is not a substitute for antiretroviral therapy.

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