Evidence supporting the use of: Vitamin B3 (nicotinamide)
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Nicotinamide (also known as niacinamide), a form of Vitamin B3, has scientific evidence supporting its use in the treatment of acne, particularly mild to moderate cases. Several clinical studies have demonstrated the effectiveness of topical nicotinamide formulations. Notably, a double-blind study published in the International Journal of Dermatology (1995) compared 4% nicotinamide gel with 1% clindamycin gel, finding both to have comparable efficacy in reducing acne lesions after 8 weeks of use. Further, a 2006 study in the Journal of Cosmetic and Laser Therapy showed that topical 2% niacinamide was effective at reducing sebum production and inflammatory lesions. Nicotinamide is thought to exert its beneficial effects through anti-inflammatory action, improvement of the skin barrier, and reduction of sebum production. It also lacks the risk of bacterial resistance associated with topical antibiotics, making it an attractive alternative or adjunct. Oral nicotinamide has less robust evidence for acne and is less commonly used for this indication. Overall, the evidence base—while not as strong as for some conventional treatments—is sufficient to justify the use of topical nicotinamide in acne management, particularly for patients seeking non-antibiotic therapies.

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