Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A (in its various forms, including retinoids) has a scientifically validated role in the treatment of acne. The connection primarily stems from the use of synthetic derivatives of vitamin A—such as tretinoin (topical) and isotretinoin (oral)—which are well-established treatments for moderate to severe acne. These compounds modulate epithelial cell growth, reduce sebum production, and have anti-inflammatory properties, all of which are key factors in acne pathogenesis.

However, "Vitamin A (mixed)" as a dietary supplement, which usually refers to a blend of preformed vitamin A (retinol or retinyl esters) and provitamin A carotenoids, does not have the same potency or pharmacological action as prescription retinoids. There is limited clinical evidence suggesting that oral vitamin A (at high doses) can improve acne, but these doses approach or exceed toxicity thresholds and are not recommended due to the risk of hypervitaminosis A. Over-the-counter vitamin A supplements have not been conclusively shown to be effective for acne in controlled trials.

In summary, while vitamin A derivatives are scientifically validated for acne treatment, the use of "Vitamin A (mixed)" supplements for acne is only weakly supported by evidence and not generally recommended due to safety concerns. The rating reflects the strong evidence for pharmaceutical derivatives, but only modest support for general supplementation.

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