Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ursane-type triterpenoids, such as ursolic acid and its derivatives, have been investigated for their potential role in supporting acne treatment, primarily due to their anti-inflammatory, antimicrobial, and anti-androgenic properties. Several in vitro studies have shown that ursolic acid exhibits inhibitory activity against Propionibacterium acnes (now Cutibacterium acnes), the bacterium implicated in acne pathogenesis. Additionally, ursolic acid has demonstrated the ability to reduce inflammation by inhibiting pathways such as NF-κB and decreasing the production of pro-inflammatory cytokines, which are involved in the development of acne lesions. Some research also suggests it may reduce sebum production via anti-androgenic effects, though this is less well-established.

Despite promising laboratory results, there is limited direct clinical evidence in humans supporting the use of ursane-type triterpenoids for acne. Most available studies are preclinical, consisting of cell culture or animal models, and robust, peer-reviewed clinical trials are lacking. Nevertheless, several topical skincare products and herbal formulations containing ursolic acid or related triterpenoids are marketed for acne, based on the mechanistic rationale and preliminary evidence. To date, the scientific support is best described as early-stage, warranting further clinical research to confirm efficacy and safety in acne patients.

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