Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phenols, a class of aromatic compounds that include derivatives like resorcinol and cresol, have a history of use in dermatology, particularly for their antiseptic and keratolytic properties. In the context of acne treatment, certain phenols—most notably resorcinol—have been incorporated in topical formulations, often in combination with other agents such as sulfur. Scientific evidence supporting their use is modest and primarily based on older clinical studies and anecdotal reports rather than large, rigorous modern trials. Resorcinol functions by breaking down rough, scaly, or hardened skin, which can help prevent pore clogging. Its mild antiseptic properties may also contribute to reducing the bacterial burden associated with acne lesions. However, due to potential skin irritation and the availability of more effective and better-studied acne treatments (e.g., benzoyl peroxide, retinoids), phenols are less commonly used today. The overall quality and quantity of clinical evidence supporting the efficacy of phenols for acne are limited, resulting in a moderate-to-low evidence rating. While their use is supported by some scientific rationale and historical clinical use, phenols are not considered first-line agents in contemporary acne management.

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