Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Phenolics, a broad class of compounds that includes substances such as salicylic acid, resorcinol, and other plant-derived phenolic acids, have a scientifically supported role in acne management. The most notable is salicylic acid (a beta-hydroxy acid), which is widely used in topical acne treatments due to its comedolytic, keratolytic, and mild anti-inflammatory properties. Salicylic acid works by promoting the shedding of dead skin cells and unclogging pores, reducing the formation of comedones. Clinical studies have demonstrated its efficacy in reducing both inflammatory and non-inflammatory acne lesions.

Other phenolic compounds derived from plants, such as polyphenols found in green tea (e.g., epigallocatechin gallate, EGCG), have shown anti-inflammatory and antibacterial activities in vitro and in some small clinical studies. These effects may help reduce the severity of acne by inhibiting the growth of Cutibacterium acnes and modulating skin inflammation. However, the evidence for these plant-derived phenolics is less robust compared to salicylic acid and is often limited to preliminary studies or adjunctive use.

Overall, there is scientific validation for the use of certain phenolics—especially salicylic acid—in acne treatment, with a moderate level of evidence (3/5) based on clinical trials and established dermatological practice. Other phenolics show promise but require further research to establish their efficacy.

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