Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacinamide (Vitamin B3) for Acne: Scientific Evidence

Niacinamide, also known as nicotinamide, is commonly included in skincare products for acne due to its well-documented anti-inflammatory and skin barrier-strengthening properties. Multiple scientific studies have investigated its efficacy in treating acne vulgaris. A pivotal double-blind study published in the International Journal of Dermatology compared 4% niacinamide gel with 1% clindamycin gel for the treatment of moderate inflammatory acne. The results showed that niacinamide was nearly as effective as clindamycin in reducing acne lesions, with the added benefit of a lower risk of antibiotic resistance.

Niacinamide’s mechanism of action for acne involves the reduction of sebum production, anti-inflammatory effects, and enhancement of the skin’s barrier function. It also reduces the activity of neutrophils, which play a role in inflamed acne lesions, and inhibits the transfer of melanosomes, thereby helping with post-inflammatory hyperpigmentation often seen in acne patients. Several clinical trials and meta-analyses support the use of topical niacinamide (usually in concentrations of 2-5%) for mild to moderate acne, both as a monotherapy and as an adjunct to other treatments.

Overall, the use of niacinamide for acne is supported by robust scientific evidence, especially for mild to moderate cases. It is generally well-tolerated, with minimal side effects, making it a popular and validated option in both over-the-counter and prescription skincare formulations.

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