Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus casei is a probiotic bacterium that has been investigated for its potential benefits in managing acne, primarily due to its role in modulating the gut microbiome and influencing systemic inflammation. Scientific interest in this area is relatively recent and stems from the growing understanding of the gut-skin axis—the concept that gut health can impact skin conditions, including acne. Several studies have shown that individuals with acne may have altered gut microbiota and increased intestinal permeability, which can contribute to systemic inflammation and exacerbate skin problems.

Preliminary clinical trials and animal studies suggest that supplementation with probiotics, including Lactobacillus casei, may reduce acne lesion counts and improve skin condition. The proposed mechanisms involve restoring gut microbial balance, enhancing the intestinal barrier, and modulating immune responses to decrease inflammation. For example, a few small-scale clinical studies have demonstrated that multi-strain probiotic supplements containing L. casei improved acne severity compared to placebo, although these studies often include other probiotic strains, making it difficult to attribute the effect solely to L. casei.

Despite promising early results, the evidence remains limited due to small sample sizes, short study durations, and heterogeneity in probiotic formulations. Therefore, while there is scientific rationale and some emerging data supporting the use of Lactobacillus casei in acne management, the evidence is currently rated as low to moderate (2/5), and further well-designed clinical trials are needed to confirm efficacy and clarify mechanisms.

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Products containing lactobacillus casei

Nature's Sunshine Bifidophilus Flora Force
Nature's Sunshine Eleven Elevated (NutriBiome)
Nature's Sunshine Probiotic Eleven
Nature's Sunshine Sunshine Heroes Probiotic Power