Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Delivery systems are scientifically validated tools used to support and treat acne, primarily by enhancing the efficacy, stability, and targeted delivery of active pharmaceutical ingredients (APIs) such as retinoids, antibiotics, benzoyl peroxide, and other agents. Acne treatments often require actives to penetrate the skin barrier and reach the pilosebaceous unit where acne originates. Conventional topical applications may have limited penetration, rapid degradation, or cause local irritation.

Advanced delivery systems—including liposomes, niosomes, solid lipid nanoparticles, nanoemulsions, and hydrogels—have been developed to address these limitations. Numerous peer-reviewed studies demonstrate that these technologies can increase the bioavailability of APIs at the target site, reduce systemic absorption (and thus side effects), and enable sustained or controlled release. For example, liposomal formulations of clindamycin and tretinoin have shown enhanced penetration with reduced irritation compared to conventional forms. Similarly, nanoparticles can protect unstable molecules like benzoyl peroxide, reducing oxidative degradation and improving tolerability.

Overall, the use of advanced delivery systems in acne therapy is supported by a robust body of scientific evidence, and many such formulations are commercially available or in development. While not all delivery systems are equally effective for all APIs, and further research is ongoing, the approach is broadly regarded as a scientifically validated advancement in acne treatment.

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