Chinese Cucumber (Trichosanthes kirilowii), also known as Tian Hua Fen, has a history of use in Traditional Chinese Medicine (TCM). It is primarily used for its purported cooling, detoxifying, and anti-inflammatory properties. In TCM, acne is often considered a manifestation of "heat" or "toxin" in the body, and Chinese Cucumber is included in some herbal formulas aimed at "clearing heat" and reducing inflammation of the skin. However, there is limited to no direct scientific evidence supporting the effectiveness of Chinese Cucumber for acne treatment specifically. Most references to its use for acne are derived from traditional herbal texts and historical practice rather than modern clinical trials or biomedical research. Existing studies on Trichosanthes kirilowii focus mainly on its potential anti-inflammatory or immunomodulatory effects, but these are not directly linked to acne in the scientific literature. Therefore, while its use is justified by tradition, the evidence base is weak and primarily anecdotal or theoretical, lacking robust scientific validation.