Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Caryophyllene, a bicyclic sesquiterpene commonly found in essential oils of plants like black pepper and cannabis, has some emerging scientific evidence supporting its potential for acne management. Its primary mechanism of interest is its anti-inflammatory activity, which has been demonstrated in several preclinical studies. Additionally, caryophyllene has shown antimicrobial properties against certain bacteria, including Propionibacterium acnes (now called Cutibacterium acnes), which is implicated in the pathogenesis of acne.

For example, a 2014 study in the journal Experimental Dermatology indicated that beta-caryophyllene could reduce inflammation in mouse skin by activating the CB2 cannabinoid receptor, which in turn lessened the inflammatory response often associated with acne lesions. Other research has highlighted caryophyllene’s antimicrobial activity, but these studies are largely in vitro and have not yet been robustly translated into clinical settings.

To date, there are no large-scale clinical trials or dermatological studies in humans specifically evaluating caryophyllene as a treatment for acne. Its evidence base is limited to laboratory and animal models, so while its use is scientifically plausible, it is not yet firmly validated or recommended as a primary intervention for acne in humans. Thus, the evidence level is rated as 2 out of 5.

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