Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylserine (PS) is a phospholipid found in high concentrations in neuronal membranes and is involved in maintaining cell structure and function in the brain. Its use as a dietary supplement is primarily aimed at supporting cognitive function and memory. There is some scientific evidence suggesting that PS supplementation can modestly improve cognitive performance, particularly in elderly individuals with mild cognitive decline. The connection to the acetylcholine system comes from PS's role in supporting neuronal membrane fluidity and facilitating signal transduction, which can indirectly support acetylcholine release and receptor function. However, the direct impact of PS on acetylcholine levels or function in humans is not robustly established. A few clinical studies have shown that PS supplementation (usually at 300 mg per day) can improve memory, attention, and other cognitive parameters, and some animal studies suggest it may enhance acetylcholine release. Nonetheless, the overall quality and quantity of evidence are limited, with most studies being small, short-term, and sometimes industry-sponsored. Thus, while PS is used to support cognitive health and may have a supportive role in acetylcholine-mediated processes, the scientific validation specifically for "acetylcholine body system support" is moderate at best.

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