Evidence supporting the use of: Choline
For the body system: Acetylcholine

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Choline is an essential nutrient that serves as a precursor for the synthesis of acetylcholine, a key neurotransmitter in the body involved in memory, muscle control, and various other functions. Scientific research confirms that choline is necessary for acetylcholine production. Studies show that choline deficiency can reduce acetylcholine synthesis, which may impair cognitive and neuromuscular function. Supplementation with choline has been demonstrated to increase plasma choline levels and, in some cases, acetylcholine levels in the brain, particularly in animal models.

However, while the biochemical role of choline in acetylcholine synthesis is clear, the evidence that choline supplementation enhances acetylcholine-dependent functions in healthy individuals is mixed. Some clinical studies suggest modest benefits for memory and cognitive function in elderly or cognitively impaired populations, but robust improvements in healthy adults are not consistently observed. There is stronger support for choline supplementation in cases of deficiency, such as in certain liver and neurological disorders or in populations with increased needs (e.g., pregnant women).

Overall, scientific validation exists for choline’s role in supporting the acetylcholine system at a biochemical level, and supplementation is justified when dietary intake is insufficient. However, evidence for widespread cognitive or performance enhancement in the general population is limited, resulting in a moderate evidence rating.

More about choline
More about Acetylcholine