Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Centrophenoxine (also known as meclofenoxate) is a compound developed in the 1950s, primarily used as a nootropic and as a potential treatment for age-related cognitive decline. Its use to support the acetylcholine system is based on its function as a cholinergic compound. Centrophenoxine is an ester of dimethylethanolamine (DMAE) and p-chlorophenoxyacetic acid. DMAE is believed to be a precursor to acetylcholine, a key neurotransmitter involved in memory and learning.

Scientific studies, mostly in animal models and limited human trials, have shown that centrophenoxine can increase brain acetylcholine levels, enhance neuronal membrane phospholipid metabolism, and reduce lipofuscin accumulation (a marker of aging) in the brain. Some small human studies in elderly populations and individuals with cognitive impairment reported modest improvements in memory, attention, and mental clarity. However, these studies are often old, small-scale, and not consistently replicated. There is a lack of robust, large-scale clinical trials confirming its efficacy for healthy individuals.

Therefore, while there is scientific rationale and some supportive data for centrophenoxine’s effect on the acetylcholine system, the overall quality and quantity of evidence is moderate to low. It is not widely used in mainstream medicine for this purpose, but it does have a historical role in nootropic and anti-aging research.

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