Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Transforming growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family and is known to play a role in cell proliferation, differentiation, and wound healing. Scientific studies, primarily in animal models and in vitro systems, have demonstrated that TGF-α can promote re-epithelialization—the process by which skin cells migrate to cover a wound—by stimulating keratinocyte proliferation and migration. For example, research has shown that topical application of TGF-α accelerates wound closure in mice and enhances the formation of new epidermal tissue. Furthermore, TGF-α has been observed to upregulate the expression of genes involved in cell migration and extracellular matrix remodeling, both of which are critical steps in the healing of abrasions and other superficial skin injuries.

Despite these promising preclinical findings, there is limited direct clinical evidence supporting the use of TGF-α as a standard or approved treatment for abrasions in humans. Most studies focus on its mechanisms or use in broader wound healing contexts, such as chronic ulcers, rather than simple abrasions. There are currently no widely accepted topical TGF-α formulations approved specifically for the treatment of abrasions. Therefore, while the scientific basis is plausible and preclinical evidence exists, robust clinical validation in the context of abrasions is lacking, resulting in a moderate evidence rating.

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