Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Mahonia species, particularly Mahonia aquifolium (Oregon grape), have a history of traditional use among indigenous peoples and in folk medicine, especially in North America and Europe, for treating minor skin injuries such as abrasions and wounds. Preparations from the bark, root, or leaves have been applied topically to support skin healing, reduce inflammation, and prevent infection. This traditional use is primarily attributed to Mahonia's content of alkaloids such as berberine, which possesses antimicrobial and anti-inflammatory properties. However, while the antimicrobial activity of berberine and related compounds is supported by laboratory studies, direct clinical evidence for the use of Mahonia preparations specifically for treating abrasions is limited. Most of the available scientific literature and clinical studies focus on Mahonia’s efficacy in managing chronic skin conditions like psoriasis, rather than acute injuries like abrasions. Therefore, while traditional use is well documented, and there is some plausibility based on known constituents, robust scientific validation for this specific application is lacking. The evidence level is rated as 2, reflecting strong tradition with some biological rationale but a lack of targeted clinical studies for abrasions.

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