Little ironweed (Vernonia cinerea) has a history of use in traditional medicine across parts of Asia, particularly in India and Southeast Asia. For abrasions and minor skin wounds, traditional healers often apply crushed leaves or extracts topically to the affected area. The rationale in folk practice is based on the plant's reputed anti-inflammatory and antimicrobial properties, which could theoretically support wound healing and infection prevention. However, scientific validation for these claims remains limited. Some laboratory studies have demonstrated that extracts of Vernonia cinerea possess antimicrobial activity against certain bacteria and fungi, as well as modest anti-inflammatory effects in vitro and in animal models. These properties could be beneficial for wound care, but there are no robust clinical trials or well-controlled studies directly examining the efficacy of Little ironweed for treating abrasions in humans. In summary, while the traditional use of Little ironweed for abrasions is documented, and preliminary laboratory evidence suggests some relevant biological activities, the overall quality and quantity of evidence is low. Its use for abrasions is thus primarily justified by ethnobotanical tradition rather than rigorous scientific proof.