Evidence supporting the use of: Hyaluronic acid
For the health condition: Abrasions

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Hyaluronic acid (HA) is scientifically validated as a treatment for abrasions and other superficial wounds. HA is a naturally occurring glycosaminoglycan found in the extracellular matrix of skin and connective tissues, where it plays a crucial role in tissue hydration, wound healing, and cell migration. Multiple clinical and preclinical studies have demonstrated that topical application of hyaluronic acid can accelerate the healing of abrasions by promoting re-epithelialization, reducing inflammation, and enhancing tissue remodeling.

A 2016 review in Dermatologic Therapy and a 2021 meta-analysis in the Journal of Cosmetic Dermatology both highlight that HA-based dressings and gels significantly improve healing rates and reduce pain in patients with acute wounds, including abrasions. The mechanism is attributed to HA’s ability to create a moist wound environment, regulate inflammatory responses, and support the migration and proliferation of keratinocytes and fibroblasts, all of which are essential for efficient wound closure.

Commercially, HA is included in various wound care products such as creams, gels, and hydrocolloid dressings. Its safety profile is favorable, and it is generally well-tolerated. While most evidence focuses on minor wounds and superficial injuries, the effectiveness of HA for abrasions is well-supported, earning it a high evidence rating.

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