Benzalkonium chloride (BZK) is a quaternary ammonium compound widely used as an antiseptic and disinfectant. Its use in the management of abrasions is primarily based on its antimicrobial properties, aiming to prevent infection in minor wounds, including abrasions. Several studies have demonstrated that BZK effectively inactivates a broad spectrum of bacteria and some viruses on the skin surface. It is a common alternative to alcohol-based antiseptics, especially for individuals sensitive to alcohol.

However, the evidence supporting BZK’s superiority or equivalence to other wound-cleansing agents (such as povidone-iodine or chlorhexidine) is limited. While laboratory studies confirm its antimicrobial activity, clinical studies directly assessing its impact on infection rates or healing outcomes in abrasions are sparse. Concerns have also been raised about potential skin irritation, allergic reactions, or delayed wound healing with repeated or prolonged use.

In summary, BZK is used in practice for cleansing abrasions, primarily to reduce the risk of infection, and this use is supported by its established antimicrobial effectiveness. Nonetheless, direct clinical evidence specifically validating improved outcomes for abrasions is limited, leading to a moderate evidence rating.