Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Nitrous oxide, also known as "laughing gas," is scientifically validated for short-term pain relief, including abdominal pain, particularly in acute settings such as the emergency department. Its analgesic and anxiolytic properties are well-documented. Nitrous oxide acts as both a sedative and analgesic, providing rapid onset of pain relief when inhaled, with effects dissipating quickly after cessation. Several randomized controlled trials and systematic reviews have evaluated its efficacy in managing pain, including acute abdominal pain secondary to procedures or conditions such as renal colic, gastrointestinal procedures, or injury-related pain.

A notable example includes studies on nitrous oxide for pain relief during procedures such as colonoscopy, where it has been shown to reduce pain and anxiety with minimal side effects. In emergency settings, self-administered nitrous oxide has been used as a non-invasive, easily titratable, and safe option for managing moderate to severe abdominal pain. Its use is often restricted to short-term management due to potential side effects and the need for monitoring, but it is particularly valued for its rapid onset and patient-controlled administration.

While it is not a definitive treatment for the underlying cause of abdominal pain, nitrous oxide is considered a scientifically validated adjunct for symptomatic relief in specific clinical scenarios. Its use is supported by guidelines in many countries, particularly for procedural pain and acute presentations in both adult and pediatric patients.

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