Withanolide
Other names for Withanolide
2.5 mg withanolides
8% withanolides
containing withanolides
standardized to contain 1.5% withanolides
supplying withanolides
total withaferin-a
total withanolides
withaferin
withaferin a
withaferine-a
withanolide
withanolide conjugates
withanolide glycoside conjugates
withanolide glycosides
withanolide glycosides conjugates
with anolides
withanolides
withanolides glycosides
withanolides note: 12.5 mg
withanolids
withanoloides
Synopsis of Withanolide
History
Withanolides are a group of naturally occurring steroidal lactones primarily found in plants of the Solanaceae family, most notably in Withania somnifera, commonly known as ashwagandha or Indian ginseng. Historically, withanolide-rich plants like ashwagandha have held a revered place in traditional Ayurvedic medicine for over 3,000 years. Ancient practitioners valued these compounds for their adaptogenic properties, believing they enhanced vitality, promoted longevity, and supported the body’s resilience to stress. Remedies containing ashwagandha were commonly prescribed to rejuvenate the body, improve sleep, restore strength after illness, and support cognitive function.
Withanolides have also been utilized in the treatment of a wide variety of conditions, including inflammation, arthritis, anxiety, and fatigue. Their anti-inflammatory and antioxidant effects have made them popular for alleviating joint pain and promoting general wellness. In traditional combinations, ashwagandha is often paired with other potent herbs such as turmeric, holy basil, and guduchi, forming synergistic blends that amplify stress relief and immune support. These herbal formulations leverage the diverse actions of multiple botanicals, with withanolides playing a central role in enhancing adaptogenic and restorative benefits.
Modern nutritional products continue to harness the broad spectrum of withanolide benefits, recognizing their potential to support mental clarity, physical endurance, and emotional balance. The historical use and enduring popularity of withanolide-containing herbs underscore their profound contributions to holistic health, making them a valuable component in both traditional and contemporary wellness regimens.
Traditional and scientific validation
Withanolides are a group of naturally occurring steroidal lactones predominantly found in the plant Withania somnifera, commonly known as ashwagandha. Ashwagandha has a long-standing history in Ayurvedic medicine, where it has been traditionally used as a rejuvenating tonic, adaptogen, and for promoting vitality and longevity. The primary bioactive constituents, withanolides, are believed to contribute significantly to its therapeutic effects.
Scientifically, withanolides have attracted attention for their potential pharmacological properties, including anti-inflammatory, antioxidant, neuroprotective, and anti-anxiety effects. Several clinical studies have explored the efficacy of ashwagandha extracts standardized for withanolide content. For example, randomized controlled trials have demonstrated that supplementation with ashwagandha may reduce stress and anxiety levels, enhance cognitive function, and support physical performance. A 2012 study published in the Indian Journal of Psychological Medicine found that ashwagandha extract significantly reduced stress and cortisol levels in adults under chronic stress, with minimal side effects.
Moreover, preliminary evidence suggests possible benefits in areas such as immune modulation and improved energy levels. However, while these findings are promising, most studies have been relatively small in scale, and more robust clinical research is needed to conclusively validate these effects and determine optimal dosing regimens. Nonetheless, the accumulating evidence, combined with centuries of traditional use, highlights withanolides as valuable contributors to nutritional products aimed at enhancing well-being.
Withanolide is used for these health conditions
Alzheimer's Disease (Traditional)
Anxiety (Traditional)
Arthritis (Traditional)
Asthma (Traditional)
Autoimmune Disorders (Traditional)
Backache (Traditional)
Cancer (natural therapy for) (Traditional)
Cancer (prevention) (Traditional)
Cancer Treatment (reducing side effects) (Traditional)
Cholesterol (high) (Traditional)
Chronic Obstructive Pulmonary Disorder (Traditional)
Circulation (poor) (Traditional)
Cirrhosis of the Liver (Traditional)
Cold Sores (Traditional)
Colds (antiviral) (Traditional)
Colds (general) (Traditional)
Concentration (poor) (Traditional)
Congestive Heart Failure (Traditional)
Constipation (adults) (Traditional)
Depression (Traditional)
Diabetes (Traditional)
Dizziness (Traditional)
Fatigue (Traditional)
Fibromyalgia Syndrome (Traditional)
Free Radical Damage (Traditional)
Gall Bladder (sluggish or removed) (Traditional)
Gastritis (Traditional)
Glaucoma (Traditional)
Hair (loss or thinning) (Traditional)
Headache (general) (Traditional)
Heart (weakness) (Traditional)
Hypertension (Traditional)
Inflammation (Traditional)
Insomnia (Traditional)
Liver Detoxification (Traditional)
Memory and Brain Function (Traditional)
Menopause (Traditional)
Mood Swings (Traditional)
Muscle Tone (lack of) (Traditional)
Nerve Damage (Traditional)
Withanolide is used to support these body systems
Adrenal Cortex (Scientific)
Adrenal Glands (Scientific)
Brain (Scientific)
Cortisol (Scientific)
Digestive System (Traditional)
Glandular System (Scientific)
Hypothalamus (Scientific)
Immune System (Scientific)
Mitochondria (Scientific)
Muscles (Scientific)
Nerves (Scientific)
Parasympathetic Nervous System (Scientific)
Reproductive System (Traditional)
Serotonin (Scientific)
Sympathetic Nervous System (Scientific)
Thyroid Gland (Scientific)
