Other names for SAMe
ademetionine 1,4-butanedisulfonate
adomix
adomix s-adenosyl-l-methionine disulfate p-toluenesulfonate
disulfate ptoluensulfonate
elemental s-adenosyl methionine
from 147 mg s-adenosylmethionine tosylate
from 245 mg s-adenosylmethionine tosylate
from 294 mg s-adenosylmethionine tosylate
from 29 mg s-adenosylmethionine tosylate
from 400mg of s-adenosyl-l-methionine disulfate p-toluenesulfonate
from 400 mg of s-adenosyl-l-methionine disulfate tosylate
from 400 mg of sam-e tosylate disulfate
from 49 mg s-adenosylmethionine tosylate
from 800mg of s-adenosyl-l-methionine disulfate p-toluenesulfonate
from 800 mg of s-adenosyl-l-methionine disulfate tosylate
from 800 mg of sam-e tosylate disulfate
from 98 mg of s-adenosylmethionine tosylate
from 98 mg s-adenosylmethionine tosylate
from 98 mg s-adenosylmethionine tosylate)
from 9 mg s-adenosylmethionine tosylate
s-adenosyl l-methionine
s-adenosyl-l-methionine
s-adenosyl-l-methionine 1,4 betandisulfonate
s-adenosyl-l-methionine bisulfate tosylate
s-adenosyl l-methionine-disulfate p-toluenesulfonate
s-adenosyl-l-methionine disulfate p-toluene sulfonate
s-adenosyl-l-methionine disulfate p-toluenesulfonate
s-adenosyl-l-methionine disulfate p-toluensulfate
s-adenosyl-l-methionine disulfate p-toluensulfonate
s-adenosyl-l-methionine disulfate p-tosylate
s-adenosyl-l-methionine disulfate tosylate
s-adenosyl l-methionine disulphate tosylate
s-adenosyl-l-methionine ion
s-adenosyl-l-methionine (same) tosylate disulfate
s-adenosyl-l-methionine tosylate
s-adenosyl l-methionine tosylate disulfate
s-adenosyl-l-methionine tosylate disulfate
s-adenosyl methionine
s-adenosyl-methionine
s-adenosylmethionine
s-adenosyl-methionine disulfate tosylate
s-adenosyl-methionine-disulfate-tosylate
s-adenosylmethionine disulfate tosylate
s-adenosyl-methionine, powder
s-adenosylmethionine tosylate
s-adenosyl methionine tosylate disulfate
s-adenosyl-methionine tosylate disulfate
s-adenosylmethionine tosylate disulfate
s-adensoyl methionine
sam-e
same
sam-e disulfate p-toluensulfonate
same disulfate p-toluensulfonate
same disulfate tosylate
{sam-e} tosylate disulfate
sam-e tosylate disulfate
same tosylate disulfate
vitamin u
vit. u
Synopsis of SAMe
History
SAMe (S-adenosyl-L-methionine) is a naturally occurring compound found in every cell of the human body, where it plays a vital role in cellular metabolism and biochemical reactions. Its medicinal use dates back to the 1950s, when Italian researchers first synthesized it and began exploring its therapeutic potential. Over the decades, SAMe has been widely recognized for its positive effects on mood regulation, liver function, and joint health.
Historically, SAMe has been utilized as a remedy for depressive disorders, particularly in Europe, where it was often prescribed as an alternative or adjunct to conventional antidepressants. Its ability to support neurotransmitter synthesis, such as serotonin and dopamine, has made it a promising natural option for mood enhancement. In addition, SAMe’s contribution to the synthesis of glutathione—a powerful antioxidant—underpins its traditional application in supporting liver detoxification and recovery from liver disease, such as hepatitis and cirrhosis.
In the realm of joint health, SAMe has been lauded for its anti-inflammatory and cartilage-protective properties, making it a popular supplement for alleviating symptoms of osteoarthritis. Its efficacy in reducing pain and improving mobility rivals that of some non-steroidal anti-inflammatory drugs, but with a more favorable safety profile.
When combined with herbal remedies, SAMe is often paired with nutrients and botanicals like St. John’s Wort, B vitamins, and milk thistle to enhance its mood-lifting and liver-supportive effects. These synergistic blends further amplify SAMe’s positive contributions to overall health and well-being, making it a valued ingredient in modern nutritional products.
Traditional and scientific validation
S-adenosylmethionine (SAMe) is a naturally occurring compound found in virtually every tissue and fluid in the human body. It has a central role in cellular metabolism, particularly in methylation reactions, which are critical for neurotransmitter synthesis, liver function, and joint health. Since its discovery in the 1950s, SAMe has been studied for its potential therapeutic benefits in various conditions, primarily as a dietary supplement.
Clinical studies have provided promising, though not definitive, evidence for SAMe’s efficacy. For mood disorders, especially mild to moderate depression, several randomized controlled trials and meta-analyses have demonstrated that SAMe can be as effective as some conventional antidepressants, with a favorable side effect profile. The compound’s role in supporting joint health, particularly in osteoarthritis, has also been explored. Research suggests that SAMe may reduce pain and improve mobility, with effects comparable to nonsteroidal anti-inflammatory drugs (NSAIDs), but with fewer gastrointestinal side effects.
In liver health, SAMe has been investigated for its ability to support liver function in individuals with cholestasis and liver disease, though results are mixed and further research is warranted. While enthusiasm for SAMe’s potential is supported by decades of scientific inquiry, it is important to note that more large-scale, long-term studies are needed to fully validate its uses. Nevertheless, SAMe remains a valuable and well-tolerated option in nutritional supplementation, with continuing research likely to further clarify and expand its applications.
SAMe is used for these health conditions
Alzheimer's Disease (Scientific)
Depression (Scientific)
Fibromyalgia Syndrome (Scientific)
Liver Detoxification (Scientific)
