Paeoniflorin
Synopsis of Paeoniflorin
History
Paeoniflorin is a prominent bioactive compound derived primarily from the root of Paeonia lactiflora, commonly known as white peony. For centuries, this botanical has played a vital role in traditional Chinese, Japanese, and Korean medicine. Historically, paeoniflorin-rich peony root was prized for its gentle yet effective properties, and was often used to harmonize and nourish the blood, calm the mind, and relieve pain. Classic remedies utilized it for easing menstrual discomfort, alleviating muscle cramps, and supporting women’s reproductive health. Its soothing properties also found application in treating headaches, dizziness, and irritability.
Paeoniflorin’s therapeutic potential extends further when used in synergistic herbal formulas. In Traditional Chinese Medicine, it is a fundamental ingredient in renowned formulas like “Shaoyao Gancao Tang” (Peony and Licorice Decoction) and “Dang Gui Shao Yao San,” where it is combined with herbs such as licorice root, angelica, and others. These combinations enhance its effects, helping to relax muscles, reduce spasms, and promote circulation. Modern research has confirmed paeoniflorin’s anti-inflammatory, antioxidant, and neuroprotective properties, supporting its traditional uses.
Overall, paeoniflorin continues to be a treasured component in both historical and contemporary herbal practice. Its gentle action, safety profile, and proven efficacy make it a valuable ally in natural medicine, particularly for supporting women’s health, soothing pain, and providing holistic wellness benefits.
Traditional and scientific validation
Paeoniflorin is a prominent bioactive compound extracted primarily from the roots of Paeonia lactiflora (white peony), a plant valued for centuries in traditional Chinese medicine. Historically, paeoniflorin-containing preparations have been used to address a variety of ailments, including menstrual discomfort, inflammatory disorders, and liver-related issues. These uses are largely based on empirical observations and traditional practices, underscoring its longstanding reputation for promoting overall health and well-being.
In recent years, scientific interest in paeoniflorin has increased, leading to a growing body of preclinical and clinical research. Laboratory studies suggest that paeoniflorin exhibits a variety of pharmacological effects, including anti-inflammatory, antioxidant, neuroprotective, and immunomodulatory actions. For instance, in vitro and animal models have demonstrated its potential to inhibit inflammatory cytokines and reduce oxidative stress, mechanisms that may underpin its traditional uses.
Some clinical studies have explored paeoniflorin's effects as part of multi-component herbal formulas. For example, Shakuyaku-kanzo-to, a traditional Japanese formula containing paeoniflorin, has shown promise in mitigating muscle cramps and aiding neurological recovery in certain patient populations. Additionally, preliminary clinical trials have suggested possible benefits for conditions such as rheumatoid arthritis and dysmenorrhea, although results are not yet conclusive and often confounded by the presence of other herbal ingredients.
While paeoniflorin’s precise therapeutic potential in humans requires further high-quality, large-scale clinical validation, current evidence highlights its promising bioactivities and supports continued research. Its longstanding historical use, combined with emerging scientific data, make paeoniflorin a noteworthy ingredient in modern nutritional and health products.
Paeoniflorin is used for these health conditions
Abdominal Pain (Traditional)
Alzheimer's Disease (Scientific)
Anxiety (Scientific)
Arthritis (Scientific)
Asthma (Traditional)
Cancer (natural therapy for) (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Cardiovascular Disease (Scientific)
Chronic Obstructive Pulmonary Disorder (Scientific)
Circulation (poor) (Traditional)
Depression (Scientific)
Diabetes (Scientific)
Dizziness (Traditional)
Fatigue (Traditional)
Fever (Traditional)
Gastritis (Scientific)
Headache (general) (Traditional)
Headache (tension) (Traditional)
Hypertension (Scientific)
Inflammation (Scientific)
Insomnia (Traditional)
Liver Detoxification (Traditional)
Memory and Brain Function (Scientific)
Migraine (Traditional)
Neuralgia and Neuritis (Scientific)
Neurosis (Scientific)
Osteoporosis (Scientific)
Pain (general remedies for) (Scientific)
Parkinson's Disease (Scientific)
Psoriasis (Scientific)
Paeoniflorin is used to support these body systems
Blood (Traditional)
Brain (Scientific)
Circulatory System (Scientific)
Digestive System (Traditional)
Gastrointestinal Tract (Traditional)
Immune System (Traditional)
Intestinal System (Traditional)
Joints (Traditional)
Liver (Traditional)
Nerves (Traditional)
Spleen (Traditional)
Uterus (Traditional)
