Lactoperoxidase
Synopsis of lactoperoxidase
Lactoperoxidase is a heme-containing enzyme naturally present in mammalian milk, saliva, tears, and other mucosal secretions. It plays a vital role in the innate immune system by catalyzing the oxidation of thiocyanate ions (SCN⁻) in the presence of hydrogen peroxide (H₂O₂), generating antimicrobial compounds like hypothiocyanite (OSCN⁻). These reactive molecules inhibit the growth of bacteria, viruses, and fungi, especially in mucosal environments.
In the human body, lactoperoxidase is part of the first line of defense on epithelial surfaces, where it protects against pathogens without relying on inflammatory processes. It is particularly effective at controlling microbial populations in the oral cavity, respiratory tract, gastrointestinal system, and mammary glands. In commercial use, lactoperoxidase is often incorporated into oral hygiene products, wound care creams, and preservative systems for cosmetics and food packaging due to its antimicrobial action.
Lactoperoxidase is also gaining attention for its potential benefits in managing oral infections, reducing dental plaque, supporting wound healing, and enhancing mucosal immunity. It is sometimes included in supplements and formulations designed to support the oral microbiome, reduce inflammation, and promote tissue integrity.
Historical Use:
Although lactoperoxidase as an isolated enzyme was not identified until the mid-20th century, its protective effects were unknowingly relied upon for centuries through the use of raw milk and traditional milk-based remedies. Before pasteurization, raw milk—especially fresh from cows, goats, or humans—contained active antimicrobial components like lactoperoxidase, lactoferrin, and immunoglobulins. These natural defenses helped suppress spoilage and disease-causing bacteria, making raw milk relatively stable and beneficial in some traditional diets.
In many cultures, fresh milk and colostrum were used to treat infections, soothe inflamed tissues, and promote wound healing. For example, raw milk was applied to skin irritations, ulcers, or eye infections in folk remedies, particularly in rural communities across Europe, the Middle East, and Africa. Although the mechanism was unknown, the lactoperoxidase system was likely at work, providing a mild but effective antimicrobial barrier.
In oral health, early remedies for gum disease or bad breath often involved rinsing with milk, whey, or other naturally fermented fluids—many of which contained peroxidase activity. These traditions mirror the modern use of lactoperoxidase in enzyme-based toothpaste and mouthwash formulations.
Today, lactoperoxidase is harnessed in purified and stabilized forms to bring ancient microbial protections into modern health, dental, and skincare applications, offering a natural defense system rooted in biology and tradition.
Lactoperoxidase is used for these health conditions
Acne (Scientific)
Antibiotics (alternatives to) (Scientific)
Bronchitis (Scientific)
Canker Sores (Scientific)
Colds (antiviral) (Scientific)
Conjunctivitis (Scientific)
Cuts (Scientific)
Dermatitis (Scientific)
Fungal Infections (Scientific)
Gingivitis (Scientific)
Herpes (Scientific)
Impetigo (Scientific)
Infection (Scientific)
Infection (bacterial) (Scientific)
Infection (viral) (Scientific)
Influenza (Scientific)
Mastitis (Scientific)
Oral Surgery (Scientific)
Skin (infections) (Scientific)
Staph Infections (Scientific)
Thrush (Scientific)
Tooth Decay (Scientific)
Ulcerations (external) (Scientific)
Wounds and Sores (Scientific)
lactoperoxidase is used to support these body systems
Gastrointestinal Tract (Scientific)
Gums (Scientific)
Immune System (Scientific)
Mucus Membranes (Scientific)
Teeth (Scientific)
